Peter Weller's character is noted as having a medical condition called "Taggart's Syndrome". Taggart was the name of Weller's character in the TV series Odyssey 5, which Manny Coto created and executive produced before he became executive producer of Star Trek: Enterprise.

Archer's speech to an alien conference and the positive reaction mirrors Kirk's speech at Khitomer at the end of Star Trek VI: The Uniscovered Country.